METHOD FOR NEW SYNTHESIS OF 1D-CHIRO-INOSITOL AND INTERMEDIATE

摘要

PROBLEM TO BE SOLVED: To provide a new method for synthesizing high-purity 1D-chiro-inositol more inexpensively and more efficiently than a conventional already-known method for producing 1D-chiro-inositol. SOLUTION: A 2,3-acetal of myo-inositol of formula (I) is subjected to selective organic sulfonylation, further a hydroxyl protecting group is introduced into the sulfonylated compound, which is reacted with an alkali metal salt of carboxylic acid in a nonreactive polar solvent under heating to form a compound of formula (VI). The compound of formula (VI) is deprotected to form 1D-chiro-inositol of the formula (A).