| 摘要 |
These desoxycyclodepsipeptides have the formula (I) wherein: C=X1, C=X2, C=X3 and C=X4 are independently CO, CS or CH2 with at least one of these groups being represents CH2; R1 and R2 are independently hydrogen, alkyl, hydroxymethyl or alkoxymethyl; R3 and R4 are independently alkyl, or optionally W substituted phenyl or benzyl; W is halogen, nitro, cyano, carbonyl, alkoxycarbonyl, alkyl, -CH(R13)NR14R15, alkenyl, alkoxycarbonylalkenyl, alkynyl, alkoxycarbonylalkynyl, hydroxyl, alkoxy, alkoxyalkoxy, alkoxyalkoxyalkoxy, dialkylaminoalkoxy, or optionally substituted aryl, arylalkyl, aryloxy or arylmethoxy; or heterocyclylmethoxy, -NR16R17, -SO2-NR16R17, -SR18, -S(O)R18 or-S(O)2R18; R5, R6, R7 and R8 are independently hydrogen, optionally amino- or hydroxyl-substituted alkyl; or mercapto, methyl, methylthioethyl, carboxymethyl, carboxyethyl, carbamoylmethyl, carbamoylethyl, guanidinopropyl or optionally amino-, nitro-, halogen-, hydroxyl- or methoxy-substituted phenyl or benzyl; naphthylmethyl, indolylmethyl, imidazolylmethyl, triazolylmethyl or pyridylmethyl where functional groups may optionally be protected and R9, R10, R11 and R12 are independently hydrogen or optionally substituted alkyl. An endo parasitical composition thereof is disclosed
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