| 摘要 |
A benzenesulfonamide compound of the formula (I)(R1 is hydroxy, C1~4 alkoxy, NR6R7 (each R6 and R7 is, independently, H or C1~4 alkyl.); R2 is H, C1~4 alkyl; R3, R4 are C1~4 alkyl, halogen trifluoromethyl; R5 is H, C1~4 alkyl, halogen, trifluoromethyl; Y is cis-vinylene, trans-vinylene; and the symbol (i)is single bond, double bond.), non-toxic salt thereof or cyclodextrin clathrate thereof and an antagonist of EP1 receptor which is a prostaglandin E2 receptor subtype comprising it as an active ingredient.The present invention compounds of the of the formula (I) can bind strongly to EP1 receptor which is a prostaglandin E2 receptor subtype and scarcely bind to the other receptor subtypes. Therefore, they are considered to be useful as antipyretic agents, as analgesics or as treating agent for pollakiuria having little side effect.
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