| 摘要 |
PROBLEM TO BE SOLVED: To provide an improved fermentative method for producing an L- amino acid, especially L-lysine and L-isoleucine by using a new nuclestide encoding lrp gene and a coryneform bacterium. SOLUTION: A polynucleotide is isolated from coryneform bacterium containing (a) a polynucleotide having at least 70% homology to a polynucleotide encoding a polypeptide having a specific amino acid sequence derived from Corynebacterium glutamicum, (b) a polynucleotide encoding a polynucleotide containing an amino acid sequence having at least 70% homology to the amino acid sequence, (c) a polynucleotide complementary to the polynucleotide of (a) or (b) and (d) a polynucleotide sequence selected from a polynucleotide having at least 15 continuous bases of the polynucleotide sequence of (a), (b) or (c). The fermentative method for producing an L-amino acid comprises using amplification or attenuation of the lrp gene. |
