发明名称 Azahexane derivatives as substrate isosters of retroviral asparate proteases
摘要 The invention relates to compounds of formula (I):wherein R1 and R10 are each independently of the other lower alkoxycarbonyl; either R2, R3 and R4 are each independently of the other C1-C4alkyl and R7, R8 and R9 are each selected from hydrogen and C1-C4alkyl, with not more than 2 of the radicals being hydrogen; or R7, R8 and R9 are each independently of the other C1-C4alkyl and R2, R3 and R4 are each selected from hydrogen and C1-C4alkyl, with 1 or 2 of the radicals being hydrogen; R5 is phenyl or cyclohexyl; and R6 is phenyl or cyanophenyl; or salts thereof; those compounds are inhibitors of retroviral aspartate proteases and are effective, for example, against HIV.
申请公布号 US6225345(B1) 申请公布日期 2001.05.01
申请号 US19980068876 申请日期 1998.05.21
申请人 NOVARTIS AG 发明人 FäSSLER ALEXANDER;BOLD GUIDO;CAPRARO HANS-GEORG;LANG MARC
分类号 A61K31/00;A61K31/27;A61K31/275;A61P31/00;A61P31/18;A61P43/00;C07C271/22;(IPC1-7):A61K31/27;C07C271/10;C07C269/04 主分类号 A61K31/00
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