FAB I INHIBITORS

摘要

Compounds of formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections. In said formula, (A) is (a) , (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o) or (p); (I) wherein R1 is H or C1-4alkyl; R2 is H, C1-4alkyl or C3-6cycloalkyl; R3 i s (q), (r), (s), (t), (u), (v) or (w); R4 is H or C1-4alkyl; (x) indicates tha t one of the two designated bonds is a double bond and the other is a single bond; R5 is CH2 when the bond to which it is attached is a double bond; or R 5 is H or C1-4alkyl when the bond to which it is attached is a single bond; R6 is H or C1-4alkyl; R7 is H, C1-6alkyl or -C0-6alkyl-Ar; Y is H, C1-4alkyl, N(R')2, NHC(O)R', NHCH2C(O)R' or NHC(O)CH=CHR'; each X independently is H, C 1- 4alkyl, CH2OH, OR', SR', CN, N(R')2, CH2N(R')2, NO2, CF3, CO2R', CON(R')2, COR', NR'C(O)R', F, Cl, Br, I or -S(O)rCF3; W is S or O, Q is H or C1-4alkyl ; M is CH2 or O; L is CH2 or C(O); E is O or NR'; each R' independently is H, C1- 6alkyl or -C0-6alkyl-Ar; and r is 0, 1 or 2; or a pharmaceutically acceptabl e salt thereof.