CARACTERIZATION AND PRESERVATION OF VACCINE FORMULATIONS

摘要

System for the thermophysical caracterization of formulations and method for the preservation of Vibrio cholerae independently of the biotype, serotype or serogroup, intended to the preparation of oral vaccines. It comprises the use of formulations with adequate proportions of at least three components which are representative of the following groups: proteins, peptides, polymers, skimmed milk, glycin and sorbitol which guarantee an incipient fusion temperature in excess -20 DEG C. Viability losses are lower than 0.7 in logarithmic order.