<p>The applicants have discovered novel chimeric and humanized anti-human CD40 antibodies which block the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent antigens, collagen induced arthritis, and skin transplantation, and are also useful for their anti-inflammatory properties.</p>
申请公布号
LV12561(B)
申请公布日期
2001.03.20
申请号
LV20000000107
申请日期
2000.08.23
申请人
BRISTOL-MYERS SQUIBB COMPANY
发明人
ARUFFO,ALEJANDRO, A.;HOLLENBAUGH,DIANE;SIADAK,ANTHONY, W.;BERRY,KAREN, K.;HARRIS,LINDA, J.;THORNE,BARBARA, A.;BAJORATH,JURGEN;WU,HERREN;HUSE,WILLIAM, D.;WATKINS,JEFFRY, D.
