VACCINE COMPOSITION

摘要

A pharmaceutical composition comprising: (i) a biologically active agent; (ii) an adjuvant chemical which increases the effect of the biologically active agent, said chemical selected from one or more of: A) a polyamino acid, B) a vitamin or vitamin derivative, C) cationic pluronics, D) a clathrate, E) a complexing agent, F) cetrimides, G) an S-layer protein, or H) methyl-glucamine; (iii) a pharmaceutically acceptable carrier or diluent, provided that when the chemical (ii) above is selected from D) or E), the biologically active agent is an agent which is capable of generating a protective immune response in an animal to which it is administered. The composition, which may be in the form of a solution or particles such as microspheres or liposomes, is particularly useful for mucosal administration of vaccines especially be the intra-nasal route or by parenteral routes.