发明名称 |
ALPHA-HYDROXY-GAMMA-[[(CARBOCYCLIC-OR HETEROCYCLIC-SUBSTITUTED)AMINO]CARBONYL]ALKANAMIDE DERIVATIVES AND USES THEREOF |
摘要 |
Certain .alpha.-hydroxy-.gamma.-[[(carbocyclic- or heterocyclic- substituted)amino]carbonyl]alkanamide derivatives are described as inhibitor s of HIV protease and inhibitors of HIV replication. These compounds are usefu l in the prevention or treatment of infection by HIV and the treatment of AIDS , either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals , immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.</SDO AB>
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申请公布号 |
CA2375954(A1) |
申请公布日期 |
2001.01.25 |
申请号 |
CA20002375954 |
申请日期 |
2000.07.19 |
申请人 |
MERCK & CO., INC. |
发明人 |
RANO, THOMAS;RAGHAVAN, SUBHAREKHA;LU, ZHIJIAN;HUENING, TRACY;TATA, JAMES R.;CHAREST, MARK |
分类号 |
A61K31/401;A61K31/422;A61K31/426;A61K31/427;A61K31/4355;A61K31/4439;A61K45/00;A61K45/06;A61P31/18;A61P43/00;C07D207/16;C07D277/06;C07D311/68;C07D405/12;C07D405/14;C07D413/12;C07D417/12;C07D417/14;C07D491/04;C07D491/048;(IPC1-7):A01N43/16;A61K31/35;A01N43/36;A61K31/40;A01N43/40;A61K31/42;A01N43/42;A61K31/425;A61K31/44;A01N43/76;A01N43/78 |
主分类号 |
A61K31/401 |
代理机构 |
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