发明名称 |
METHOD FOR DOWN-REGULATING GDF-8 ACTIVITY |
摘要 |
Disclosed are novel methods for increasing muscle mass by means of immunization against Growth Differentiation Factor 8 (GDF-8, myostatin). Immunization is preferably effected by administration of analogues of GDF-8 which are capable of inducing antibody production against homologous GDF-8. Especially preferred as an immunogen is homologous GDF-8 which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes while substantially preserving the tertiary structure of the homologous GDF-8. Also disclosed are nucleic acid vaccination against GDF-8 and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for identification of useful immunogenic GDF-8 analogues, methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
|
申请公布号 |
WO0105820(A2) |
申请公布日期 |
2001.01.25 |
申请号 |
WO2000DK00413 |
申请日期 |
2000.07.20 |
申请人 |
M & E BIOTECH A/S;HALKIER, TORBEN;MOURITSEN, SOEREN;KLYSNER, STEEN |
发明人 |
HALKIER, TORBEN;MOURITSEN, SOEREN;KLYSNER, STEEN |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K38/18;A61K39/00;A61K39/39;A61K48/00;A61P5/02;A61P21/00;A61P43/00;C07K;C07K14/475;C07K14/52;C12N1/11;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12Q1/02;(IPC1-7):C07K14/00 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|