Method for preparing 5-substituted oxazoles

摘要

The invention provides a method for the preparation of 5-substituted oxazoles in high yield using inexpensive, widely available reagents. The method is particularly useful in the preparation of intermediates necessary in the synthesis of a class of IMPDH inhibitors, in particular VX-497, which is currently in clinical trials. The invention also provides compounds that represent novel intermediates useful in the methods of this invention.