Fused polycyclic 2-aminopyrimidine derivatives

摘要

Fused polycyclic 2-aminopyrimidines of formula (1) are described: wherein R1 is a group -L1 R2 where L1 is a covalent bond or a linker atom or group and R2 is a group -(Alk)mL2R3 where Alk is an optionally substituted aliphatic or heteroaliphatic chain, m is zero or the integer 1, L2 is a covalent bond or a linker atom or group and R3 is an optionally substituted cycloaliphatic or heterocycloaliphatic group provided that when m is zero L2 is a covalent bond; Ar is an aryl or heteroaryl group; X is a carbon or nitrogen atom; Y is a carbon or nitrogen atom; Z is a linker group; A together with X and Y forms an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are potent and selective inhibitors of protein kinases, especially src-family protein kinases and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to have a role.