| 摘要 |
PURPOSE: A fermentative process for the production of penicillin G or V or cephalosporin G or V derivatives, is provided, wherein certain derivatives of phenylbutyric acid are used as a side chain precursor. CONSTITUTION: A process for producing an N-phenylacetyl or an N-phenoxyacetyl penam or cephem compound, optionally including deacylating said N-phenylacetyl orN-phenoxyacetyl penam or cephem compound, comprises the steps of: fermenting a suitable penam- or cephem-producing strain in a fermentation medium in the presence of a side chain precursor according to formula 1, wherein -R, and -R3 are selected from the group consisting of -OH, =O or -H,where -R, and -R3 can be the same or different, with the proviso that -R, and -R3 are not both -H or =O; -R2 or -R4, respectively, is -H if -R, or -R3, respectively, is -OH or -H; -R2 or -R4, respectively, is not present if -R, or -R3, respectively, is =O; -R5 is -OR6 or -NH2, wherein R6 is selected from the group consisting of -H, -CH3 or -CH2CH3; m is 0 or 1; n is an odd number from 1 up to 15, the carbon chain optionally containing on or more double bonds, and recovering the produced N-phenylacetyl or N-phenoxyacetyl penam or cephem compound from the fermentation broth, and optionally deacylating the produced N-phenylacetyl or N-phenoxyacetyl penam or cephem compound and recovering the corresponding deacylated penam or cephem compound.
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