Glycosylation-mediated inhibition of factor X

摘要

PCT No. PCT/US93/02203 Sec. 371 Date Dec. 2, 1994 Sec. 102(e) Date Dec. 2, 1994 PCT Filed Mar. 11, 1993 PCT Pub. No. WO93/18782 PCT Pub. Date Sep. 30, 1993Reagents that specifically bind a carbohydrate target wherein sialic acid is linked at the nonreducing terminus of a glycoside to a galactose or galactosamine residue through an alpha 2-6 linkage are able to inhibit the conversion of human Factor X to human Factor Xa. These reagents (SA/Gal/GalNAc binding reagents) as well as other strategies for inhibiting the conversion of Factor X to Factor Xa are useful in treating thrombosis, inflammation and other conditions associated with excess thrombin activity.