SUBSTITUTED ACETYLPYRIDINE DERIVATIVES AND PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR OPTICALLY ACTIVE .BETA.3 AGONIST BY THE USE OF THE SAME

摘要

An industrially useful process for preparing safely and efficiently intermediates for optically active .beta.3 adrenergic receptor agonist from easily available raw materials, which comprises reducing a substituted acetylpyridine derivative represented by general formula (9) enantio- selectively into an optically active hydroxyethylpyridine derivative represented by general formula (10) (wherein * represents an asymmetric carb on atom), and converting this derivative into an intermediate for optically active .beta.3 adrenergic receptor agonist, e.g., an optically active dihydroxyethylpyridine derivative represented by general formula (14) or an optically active oxirane derivative represented by general formula (16).