发明名称 ERYTHRO-(E)-3,5-DIHYDROXY-7-(3'-(4''-FLUOROPHENYL-1'-(1''- -METHYLETHYL)INDOL-2'-YL)HEPT-6-ENIC ACID AND PROCESS FOR PREPARING THEREOF
摘要 Disclosed is the compound of formula (Ia) in racemic or optically pure form, in free acid, salt, ester or delta-lactone, i.e. internal ester, form; and a process for preparing thereof by stereoselective reduction of a corresponding compound of formula (IIa), wherein R1 is an ester group inert to the reaction conditions, such as alkyl having from 1 to 4 carbon atoms or benzyl. The compounds disclosed exhibit antiatherosclerotic, antihyperlipidemic and antihypercholesterolemic activities.
申请公布号 SK280845(B6) 申请公布日期 2000.08.14
申请号 SK19890005797 申请日期 1989.10.12
申请人 NOVARTIS AG 发明人 CHEN KAU-MING;KAPA PRASAD KOTESWARA;LEE GEORGE T.;REPIC OLJAN;HESS PETR;CREVOISIER MICHEL
分类号 C07D209/10;A61K31/40;A61K31/403;A61K31/404;A61K31/405;A61P3/06;C07B57/00;C07C51/367;C07C59/11;C07C59/13;C07C59/135;C07C59/48;C07C67/31;C07C69/675;C07C69/732;C07C209/24;C07C223/02;C07D209/12;C07D209/18;C07D209/24;C07D233/54;C07D309/30;C07D405/06 主分类号 C07D209/10
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