| 摘要 |
PURPOSE: Provided is a method for inhibiting stress-activated protein kinases (SAPKs) which comprises administering to a mammal in need thereof an effective amount of a compound which is a dual non-selective beta-adrenoceptor and alpha 1-adrenoceptor antagonist. CONSTITUTION: Provided is a new method for inhibiting stress-activated protein kinases using compounds which are dual non-selective beta-adrenoceptor and alpha-adrenoceptor antagonists. Preferably, A new method for inhibiting stress-activated protein kinases using compounds of Formula 1 is provided wherein: R7-R13 are independently -H or-OH; and A is a moiety of Formula 2 wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl; R3 is hydrogen or lower alkyl of up to 6 carbon atoms; R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent -CH2-0-; X is a single bond, -CH2, oxygen or sulfur; Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl; R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a -CONH2- group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms; or R5 and R6 together represent methylenedioxy; and pharmaceutically acceptable salts thereof.
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