| 摘要 |
<p>A method for treatment of severe chronic bronchitis (bronchiectasis) using a concentrated aminoglycoside antibiotic formulation delivering the antibiotic to the lung endobronchial space including alveoli in an aerosol or dry powder having mass medium diameter predominately between 1 to 5 microns. The method comprises administration of the antibiotic in a concentration one to ten thousand times higher than the minimal inhibitory concentration of the target organism. Preferably, the method comprises endobronchial administration of aerosol or dry powder tobramycin to treat pseudomonal infections in severe chronic bronchitis (bronchiectasis) patients.</p> |
