| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain the subject inhibitor having an activity of inhibiting the production of IgE and IL-5, showing an effect to acute and chronic allergic diseases and useful for the prevention and treatment of the allergy by including a specific phthalimide derivative as an active ingredient. SOLUTION: This medicine contains a phthalimide derivative of the formula R1 to R4 are each H, OH, a lower alkyl or the like; A is CB1 [B1 is H, a lower alkyl or the like] or N; B is H, a (substituted) lower alkyl or the like; X is a 1-4C alkylene or the like: Y is O, NR6 (R6 is H or a lower alkyl) or S; Z is a 1-4C alkylene, a 2-4X alkenylene or the like; (l), (m), (n) are each 0, 1; Cy is a cross-linked cyclic hydrocarbon} or its pharmaceutically permissible salt, preferably 2-[(S)-2-(adamantan-1-ylmethoxy)-1-phenylethyl]-2,3-dihydro-1,3- dioxo-1H-isoindole-5-carboxylic acid, etc., as an active ingredient.</p> |
