| 摘要 |
1,170,059. Medicines containing synthetic resins. MONSANTO CO. 13 Dec., 1966 [13 Dec., 1965], No. 55815/66. Addition to 1,156,010. Heading A5B. The invention comprises compositions of a biologically active substance and an aminopolyamide resin comprising from 1.5 to 8.5% by weight of amino nitrogen, from 5.5 to 19.8% by weight of amide groups and from 78.7 to 86% by weight of hydrocarbon moiety, which moiety may contain one or more hetero atoms, provided that when the hydrocarbon moieties exceed 83.1% by weight, the amine content is greater than 4.35% by weight. The aminopolyamides are generally prepared from a carboxylic acid and an amine. A large number of those reactants are specified including the following polymerized linoleic acid as a carboxylic acid; ethylene, propylene, tetramethylene and phenylene diamines as an amine. The biologically active substance may be a nutrient such as amino acids e.g. lysine, methionine; amino acid analogues e.g. methionine hydroxy analogue (OH in place of NH 2 ); soyabean; antibiotics e.g. procaine penicillin 9, bacitracin, streptomycin, erythiomycin chlorotetracycline and oxytetracycline; sulfa drugs e.g. sulfamethazine and sulfanilamide; sedatives e.g. amytal, phenobarbital. sodium pentabarbital and cyclopentenyl barbituric acid anthelmintics e.g. phenothiazine, 2-(4'-thiazolyl) benzimidazole and piperazine derivatives; antipyretics e.g. aspirin and sodium salicylate; hormones e.g. androgenic steroids, estrogenic steroids and hydrocortisone; hypoglycaemic agents such as sulfonylureas and biguanides e.g. N-(N-#-phenethylformamidinyl) iminourea and 1-(p-tolyl)-3-n butylsulfonyl urea; antispasmodics, haematics, laxatives, expectorants and/or other growth promoting agents. The biologically active substance may be in the form of particles or globules which are coated with the resin or suspended in a matrix of the resin; alternatively the resin may enclose the biologically active substance. The resins resist the action of the rumen microflora and the compositions may be administered to ruminants in their feed. |
