Apparatus and method for sealing a plurality of chromatography columns

摘要

An apparatus and method for sealing a plurality of columns containing media for use in liquid chromatography. The invention involves two sealing assemblies, each having a plurality of sealing heads. The sealing heads are sized to receive ends of the columns and to seal the columns when the heads are compressed. Compressive force is exerted by or through springs to permit the sealing heads to adapt to the length of the media bed within each column. The apparatus may include a pressure containment vessel for subjecting the columns to radial compression.