发明名称 |
METHOD FOR INDUCING A CELL-MEDIATED IMMUNE RESPONSE AND PARENTERAL VACCINE FORMULATIONS THEREFOR |
摘要 |
A method of inducing either a TH1 polarised immune response, a TH2 polarised immune response or a combined TH1 and TH2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for inducing a polarised TH1 response by parenteral administration of microparticles sized such that at least 50 % of the microparticles are less than 5 mu m, the microparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Additionally, a method is provided for inducing a polarised TH2 response by parenteral administration of nanoparticles sized such that at least 50 % of the nanoparticles are less than 600 nm, the nanoparticles containing antigen entrapped or encapsulated by a biodegradable polymer. Vaccine formulations containing the B.pertussis antigens PTd, FHA or a combination of PTd and FHA are provided.
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申请公布号 |
WO0012125(A1) |
申请公布日期 |
2000.03.09 |
申请号 |
WO1999IE00087 |
申请日期 |
1999.08.31 |
申请人 |
ELAN CORPORATION, PLC;BRAYDEN, DAVID, JAMES |
发明人 |
BRAYDEN, DAVID, JAMES |
分类号 |
A61K9/10;A61K9/00;A61K9/16;A61K9/50;A61K9/51;A61K39/00;A61K39/10;A61K47/34;A61P31/04;A61P37/04;B01J13/06;(IPC1-7):A61K39/00 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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