发明名称 |
Dry analytical element for acetaminophen assay |
摘要 |
A spectrophotometric assay for the detection of acetaminophen in aqueous fluids can be carried out with a dry analytical element. The element comprises a support having thereon one or more reagent layers containing a first enzyme, aryl acylamidase, to cleave the amide bond of acetaminophen to produce p-aminophenol; a second enzyme, ascorbic acid oxidase, to oxidize the p-aminophenol so that it couples to a water soluble coupling agent to form a dye that is read at 670 nm. The assay is precise, accurate on serum and plasma samples, and relatively free from significant interferences. The element also allows measurement over a broad dynamic range.
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申请公布号 |
US6015683(A) |
申请公布日期 |
2000.01.18 |
申请号 |
US19920914915 |
申请日期 |
1992.07.15 |
申请人 |
CLINICAL DIAGNOSTIC SYSTEMS, INC. |
发明人 |
SCHAEFFER, JAMES ROBERT;MAUCK, JOHN CHARLES;WINTERKORN, ROBERT FRANCIS;ARTER, THOMAS CHARLES |
分类号 |
C12Q1/00;C12Q1/34;(IPC1-7):C12Q1/37;C12Q1/26;C12Q1/28 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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