发明名称 |
Liquid phase peptide synthesis of KL-4 pulmonary surfactant |
摘要 |
The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the alpha -carbon.
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申请公布号 |
US6013764(A) |
申请公布日期 |
2000.01.11 |
申请号 |
US19970881971 |
申请日期 |
1997.06.25 |
申请人 |
ORTHO PHARMACEUTICAL CORP. |
发明人 |
ABDEL-MAGID, AHMED F.;EGGMANN, URS;MARYANOFF, CYNTHIA ANNE;THALER, ADRIAN;VILLANI, FRANK J. |
分类号 |
A61K38/00;C07K1/12;C07K5/083;C07K5/09;C07K14/785;(IPC1-7):C07K1/02;C07K1/08;C07K1/10;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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