发明名称 |
Methods for enhancing antigen-presenting cells and anti-tumor responses in a human patient |
摘要 |
The present invention provides methods for enhancing the development of APC from precursor cells by administering a combination of GM-CSF and IL-4. The precursor cells include: cells contained in peripheral blood, CD14<+> cells and precursors in bone marrow. Thus, administration of GM-CSF and IL-4 can be used as a form of cytokine immunotherapy. One embodiment of the present invention involves systemic administration of GM-CSF and IL-4. In this embodiment, APC are required to directly access tumor antigens as they exist in vivo within the patient. A further embodiment of the present invention involves co-administration of a tumor-associated or tumor-specific antigen, with GM-CSF and IL-4, to induce antigen-specific immunity mediated by APC. Yet another embodiment of the present invention describes systemic administration of GM-CSF and IL-4 to achieve reduced tumor burden. |
申请公布号 |
AU3469599(A) |
申请公布日期 |
1999.10.25 |
申请号 |
AU19990034695 |
申请日期 |
1999.04.02 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, |
发明人 |
MICHAEL DEREK ROTH;ROBERT ALAN PIGLIN;SYLVIA MARIE KIERTSCHER;BARBARA JENNIFER GITLITZ |
分类号 |
A61K48/00;A61K38/00;A61K38/20;A61K39/00;A61P35/00;A61P37/04;A61P43/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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