发明名称 |
CONJUGATES OF CYTOKINES AND DRUGS OR GENES FOR TREATING PROLIFERATING CELLS |
摘要 |
A product comprising a proliferatively active moiety, typically a cytokine or growth factor which has a high affinity receptor, linked to a biologically active agent which agent preferentially or selectively affects proliferating cells. An active promoter of proliferation, for example an active IL-2, is beneficially used to deliver pharmacologically desirable species to cells whose proliferation is not desired. For example some medicaments of the invention control or inhibit proliferation using a molecule which contains an active promoter of proliferation. The biologically active agent is usually selected from the group consisting of antiproliferative drugs, compounds which interfere with nucleotide synthesis, radioisotopes, gene sequences and antisense nucleotide sequences. |
申请公布号 |
WO9926660(A3) |
申请公布日期 |
1999.10.14 |
申请号 |
WO1998GB03509 |
申请日期 |
1998.11.25 |
申请人 |
BIOINNOVATION LIMITED;FRANKS, CHRISTOPHER, RALPH;DELLA BITTA, RUGGERO |
发明人 |
FRANKS, CHRISTOPHER, RALPH;DELLA BITTA, RUGGERO |
分类号 |
A61K38/00;A61K38/22;A61K45/00;A61K47/48;A61P43/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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