发明名称 HYPNOTIC .BETA.-CARBOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS
摘要 The present invention concerns derivatives of general formula I (I' and I''), in which X represents a divalent radical of formula (a) or (b), R1, R2, R3, and R4 represent, independently of each other, a hydrogen atom, a hydroxy radical, a lower alkyl, lower alkoxy, aryloxy, halo or nitro radical or an unsaturated aliphatic chain, lower alkylcarbonyl, lower alkylcarbonyloxy, carboxyl, these groups being optionally substituted. R5 represents a hydrogen atom, a lower alkyl, cycloalkyl, aryl, lower aralkyl, lower alkoxy, a lower alkylcarbonyl, halo(lower)alkylcarbonyl, lower alkyloxycarbonyl, amino, these groups being optionally substituted. R6, R7, R9, R10, R12, R13, R14 and R15 represent, independently of each other, a hydrogen atom, a lower alkyl, a lower cycloakyl, halo(lower)alkyl, perhalo(lower)alkyl, aryl, aralkyl, lower alkoxy, lower cycloalkoxy, mono or polyhaloalkoxy, aryloxy, aralkyloxy, hydroxyalkyl, alkyloxyalkyl, lower alkylthio, lower cycloalkylthio, these groups being optionally substituted. R8 represents a lower alkyl, a lower cycloalkyl, hydroxyalkyl, alkyloxyalkyl, halo(lower)alkyl, perhalo(lower)alkyl, aryl, these groups being optionally substituted. R11 represents an oxygen atom or a sulfur atom optionally substituted.
申请公布号 CA2324270(A1) 申请公布日期 1999.09.23
申请号 CA19992324270 申请日期 1999.03.17
申请人 MACEF;LABORATOIRES BESINS ISCOVESCO 发明人 VIOLEAU, BRUNO;FOURTILLAN, JEAN-BERNARD;JACQUESY, JEAN-CLAUDE;JOUANNETAUD, MARIE-PAULE;KARAM, OMAR;FOURTILLAN, MARIANNE
分类号 C07D221/18;A61K31/435;A61K31/437;A61K31/4375;A61P15/18;A61P21/02;A61P25/00;A61P25/04;A61P25/08;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P35/00;A61P43/00;C07D;C07D221/04;C07D455/02;C07D455/03;C07D471/04;C07D471/14;(IPC1-7):C07D471/04 主分类号 C07D221/18
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