发明名称 |
Expression systems utilizing autolyzing fusion proteins and a reducing polypeptide |
摘要 |
The present invention provides expression systems for exogenous polypeptides wherein the polypeptide is expressed as a fusion protein together with clover yellow virus Nuclear Inclusion a (NIa), the NIa component serving to autolyze the fusion protein after expression. This system can be used to express a novel polypeptide which we have designated KM31-7 protein and which is capable of reducing dichloroindophenol and reduced glutathione. This polypeptide is useful in the treatment of disorders caused by oxidative stress.
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申请公布号 |
US5955072(A) |
申请公布日期 |
1999.09.21 |
申请号 |
US19950500635 |
申请日期 |
1995.07.11 |
申请人 |
SANKYO COMPANY, LIMITED |
发明人 |
TAKAHASHI, TOHRU;SERIZAWA, NOBUFUSA;KOISHI, RYUTA;KAWASHIMA, ICHIRO |
分类号 |
C12N15/53;A61K38/00;A61K38/44;A61K39/12;A61P7/12;A61P9/10;C07K14/08;C07K14/54;C07K16/10;C07K16/40;C12N1/21;C12N5/12;C12N5/18;C12N9/02;C12N9/50;C12N15/24;C12N15/40;C12N15/62;C12N15/70;C12Q1/68;C12R1/19;G01N33/573;(IPC1-7):A61K38/43;C12N9/48;C07K1/00 |
主分类号 |
C12N15/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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