MEDICINAL AEROSOL FORMULATIONS

摘要

PCT No. PCT/GB90/01454 Sec. 371 Date Mar. 17, 1992 Sec. 102(e) Date Mar. 17, 1992 PCT Filed Sep. 20, 1990 PCT Pub. No. WO90/07333 PCT Pub. Date Jul. 12, 1990.A method for preparing a self-propelling, powder dispersing aerosol composition comprising at least 0.0001% by weight of a finely-divided solid medicament coated with a non-perfluorinated surface active dispersing agent which constitutes at least 0.0001% by weight of the coated solid material, and suspended in an aerosol propellant in which the non-perfluorinated surface-active dispersing agent is substantially insoluble. Propellant-insoluble non-perfluorinated surfactants are used to prepare stable dispersions of powdered medicament by way of pre-coating the medicament with the surfactant prior to admixture with propellant.