GENE MUTANT ANIMALS

摘要

Gene mutant animals such as mice having a mutant presenilin-1 gene which contains a DNA sequence encoding a mutant presenilin-1 protein having an amino acid sequence derived from that of presenilin-1 protein by substitution of one amino acid (for example, one wherein isoleucine at the 213-position of mousederived presenilin-1 protein has been substituted by another amino acid such as threonine). These animals are useful as model animals being pathologically closer to human patients with Alzheimer's diseases.