发明名称 Benzimidazole derivatives with antihistaminic activity
摘要 New benzimidazole derivatives of formula: <IMAGE> in which R1 is H or a short chain hydrocarbon group such as methyl, ethyl, isopropyl, cyclopropyl, vinyl, etc., and R2 is a group selected from among the following: CH2OH, COOH, COOR3 and 4,4-dimethyl-2-oxazolinyl, R3 being a short chain alkyl group such as methyl, ethyl, etc., are described. A description is also made of the preparation of these compounds, which have a high H1 antihistaminic and antiallergic activity and are devoid of effects on the central nervous and cardiovascular systems.
申请公布号 US5877187(A) 申请公布日期 1999.03.02
申请号 US19970868743 申请日期 1997.06.04
申请人 FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS S.A. (FAES) 发明人 ORJALES, AURELIO;RUBIO, VICTOR;BORDELL, MARAVILLAS
分类号 C07D403/04;A61K31/4184;A61K31/4427;A61K31/445;A61P37/08;A61P43/00;C07D235/04;C07D235/06;C07D401/04;C07D413/14;H02B11/04;H02B11/24;(IPC1-7):A61K31/445 主分类号 C07D403/04
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