IMPROVED PRECIPITATION PROCESS OF 7-AMINOCEPHALOSPORANIC ACID (7-ACA)

摘要

A process in the isolation of 7-aminocephalosporanic acid (7-ACA) of formula (I) from an alkaline, neutral or slightly acidic medium in the presence of an additive, e.g. selected from the group comprising organic carboxylic acid esters, polymeric glycols, polyacryls, amines and polyamines, melamin-formaldehyde resins or amino acids and esters thereof to obtain 7-ACA agglomerates and/or rosettes.