Hydrophilic polystyrene graft copolymer vehicle for intravaginal administration of pharmacologically active agents

摘要

This invention pertains to the vaginal delivery of pharmacologically active agents and to polymeric formulations that allow for a prolonged release of the active agents in the vaginal environment. More specically the invention pertains to compositions for the delivery of drugs intravaginally comprising a drug or a plurality of drugs to be delivered and a thermoplastic graft copolymer, said graft copolymer being the reaction product of a polystyrene macromonomer having an ethylenically unsaturated functional group and at least one hydrophilic monomer having an ethylenically unsaturated functional group.