发明名称 |
FSH AND LH SEPARATION AND PURIFICATION PROCESS |
摘要 |
A new process, particularly simple and economical, for FSH and LH separation and purification starting from crude HMG preferably urinary, comprising the following steps: optional exhaustion of crude HMG viral charge in aqueous EtOH; ion-exchange chromatography on weakly basic anionic resins of DEAE type; affinity chromatography on resin having an antraquinone derivative as a ligand; optional ion-exchange chromatography on strongly basic anionic resins. Hormones obtained thereby, in particularly pure form and having high specific activity, may subsequently undergo a depyrogenation step. |
申请公布号 |
WO9820039(A1) |
申请公布日期 |
1998.05.14 |
申请号 |
WO1997EP06058 |
申请日期 |
1997.11.03 |
申请人 |
IBSA INSTITUT BIOCHIMIQUE S.A.;LUALDI, PAOLO;DONATI, ELISABETTA;RAPAPORT, IRINA |
发明人 |
LUALDI, PAOLO;DONATI, ELISABETTA;RAPAPORT, IRINA |
分类号 |
C07K14/59 |
主分类号 |
C07K14/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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