| 摘要 |
Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 is H, C1-C4 alkyl, CN or CONR4R5;R2 is C2-C4 alkyl; R3 is SO2NR6R7, NO2, NH2, NHCOR8, NHSO2R8 or N(SO2R8) 2; R4 and R5 are each independently selected from H and C1-C4 alkyl; R6 and R7 are each independently selected from H and C1-C4 alkyl optionally substituted with CO2R9, OH, pyridyl, 5-isoxazolin-3-onyl, morpholino or 1-imidaz olidin-2-onyl; or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, morpholino, 1-py razolyl or 4-(NR10)-1 piperazinyl group wherein any of said groups may optionally be substituted with one or two substit uents selected from C1-C4 alkyl, CO2R9, NH2 and OH; R8 is C1-C4 alkyl or pyridyl; R9 is H or C1-C4 alkyl; and R10 is H, C1-C4 alkyl or (hydroxy)C2-C3 alkyl; are selective cGMP PDE inhibitors useful in the treatment of, inter alia, cardiovasc ular disorders such as angina, hypertension, heart failure and atherosclerosis.
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