A method of preparing a flexible or continuous web of material (20) for labeling/packaging a product includes printing graphics and information on the material (20) in any desired format and color utilizing a pigmented ink providing a visible light signature and printing or otherwise providing an invisible eye spot/registration mark (24) on the material (20) utilizing a composition providing a nonvisible light signature adapted to identify an end of one label/package (22) and the beginning of another. Preferably, the eye spot/registration mark (24) extends fully across one dimension (e.g. width) of the material (20). Printing compositions for the eye spot/registration mark (24) are also disclosed.