Solid coprecipitates for enhanced bioavailability of lipophilic substances

摘要

Lipophilic active ingredient are co-melted with tocopherol polyethyleneglycol succinate ("TPGS") and a dispersion adjuvant to obtain solid dry coprecipitate compositions suitable as an oral dosage form. The solid TPGS coprecipitates of lipophilic active ingredients show improved drug release in vitro and enhanced oral bioavailability in vivo.