Preparation of substituted alkenoic acids

摘要

This invention relates to a highly selective process for preparation of E- omega -phenyl- omega -(3-pyridyl)- omega -alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as to intermediates therefor.