| 摘要 |
<p>This invention concerns the compounds of formula (I), the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C1-6alkanediyl; R1 is hydrogen, C¿1-6?alkyl, aryl or arylC1-6alkyl; R?2, R3 and R4¿ are each independently selected from hydrogen, halo, hydroxy, nitro, cyano, C¿1-6?alkyl, C1-6alkyloxy, trifluoromethyl, C1-6alkylthio, mercapto, amino, mono- and di(C1-6alkyl)amino, carboxyl, C1-6alkyloxycarbonyl or C1-6alkylcarbonyl; R?5¿ is hydrogen, C¿1-6?alkyl, phenyl or phenylC1-6alkyl; R?6¿ is hydrogen, C¿1-6?alkyl, C1-6alkyloxy, C1-6alkylthio, or a radical of formula -NR?8R9¿, wherein R?8 and R9¿ are each independently selected from hydrogen, C¿1-6?alkyl, phenyl or phenylC1-6alkyl; R?7¿ is hydrogen or C¿1-6?alkyl; or R?6 and R7¿ taken together may form a bivalent radical of formula -R6-R7-; having central dopamine and serotonin antagonistic activity; their preparation, compositions containing them and their use as a medecine.</p> |
