A PROCESS FOR THE PREPARATION OF AZETIDINONES

摘要

There is described the preparation of 4-acetoxy-3-acylaminoazetidin-2-ones through the introduction of an acetoxy group in the 4 position of a 3-(N-acyl-N-protected)aminoazetidin-2-one not subtituted in the 1 position and the removal of the N-protecting group of the amine in the 3 position. The synthesis may be stereoselective in the case of the preparation of 4-acetoxy-3-phenylacetamidoazetidin-2-one if, starting from a 3-aminoazetidinone, the acylation at the 3 position is carried out with penicillanacilase. The novel 1-propenylazetidinones are furthermore described.