发明名称 2-THIOXO-IMIDAZOLIDIN-4-ONE DERIVATIVES AND THEIR USE FOR INCREASING HDL CHOLESTEROL CONCENTRATION
摘要 Compounds and a method for increasing the HDL cholesterol concentration in the blood of a mammal in need of increased HDL cholesterol blood concentration, which comprises administering to said mammal, orally or parenterally, a compound of formula (I) wherein R is alkyl; a substituted or unsubstituted aromatic N, O or S heterocycle; substituted or unsubstituted aryl, arylalkyl, benzhydryl or indanyl, in which the substituents are one to three members independently selected from the group consisting of alkyl, alkoxy, alkylthio, alkenyl, alkynyl, halo, perfluoroalkyl, perfluoroalkoxy or hydroxy; and R1 is aryl, alkyl, alkenyl, alkynyl or substituted aryl where the substituents are one to three members independently selected from the group consisting of alkyl, alkoxy, alkylthio, alkenyl, alkynyl, halo, perfluoroalkyl, perfluoroalkoxy or hydroxy.
申请公布号 CA2238762(A1) 申请公布日期 1997.06.05
申请号 CA19962238762 申请日期 1996.11.25
申请人 AMERICAN HOME PRODUCTS CORPORATION 发明人 CHAI, SIE-YEARL;STRIKE, DONALD PETER;SULKOWSKI, THEODORE SYLVESTER;ELOKDAH, HASSAN MAHMOUD
分类号 A61K31/00;A61K31/415;A61K31/4164;A61K31/4166;A61K31/4174;A61K31/4439;A61P9/00;A61P9/10;C07D233/86;(IPC1-7):C07D233/86;C07D401/04;A61K31/44 主分类号 A61K31/00
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