PROCESS FOR VIRUS DEACTIVATION IN THE PRESENCE OF POLYALKYLENE GLYCOL AND THE PHARMACEUTICAL PREPARATION THUS OBTAINED

摘要

PCT No. PCT/IB95/00019 Sec. 371 Date Jun. 28, 1996 Sec. 102(e) Date Jun. 28, 1996 PCT Filed Jan. 10, 1995 PCT Pub. No. WO95/09657 PCT Pub. Date Apr. 13, 1995The invention relates to a pharmaceutical preparation comprising a plasma protein wherein said preparation is free of infectious agents as well as essentially free of denaturation products and is obtainable by a method that encompasses the following steps: a) addition of a polyether and a chaotropic agent to a solution comprising the plasma protein, optional lyophilization of the solution; b) inactivation of infectious agents in the presence of the polyether by a physio-chemical or chemical treatment, and c) removal of the polyether and the chaotropic agent.