摘要 |
A subject-matter of the invention are oxaindene derivatives of general formula <CHEM> wherein R1 represents a C1-4-alkyl, C1-4-alkoxy or C3-6-cycloalkyl group, R2 stands for hydrogen or a C1-4-alkyl or C3-6-cycloalkyl group, R3 represents hydrogen or a C1-4-alkyl, C1-4-alkoxy or benzyloxy group, X means hydrogen, an aliphatic C1-4-acyl or benzoyl or naphthoyl group, optionally substituted by 1 or more nitro or C1-4-alkoxy group(s) or a group of formula <CHEM> in which latter R7 stands for a C1-4-alkylene group and R5 and R6 each represents a C1-4-alkyl group or R5 and R6 together with the nitrogen atom to which they are attached form a piperidyl or morpholinyl group, A and B together form an ethylene or a vinylene group and n is 1, 2 or 3, and their stereoisomers and their mixtures as well as acid addition salts of these compounds. Moreover there are provided for a process for preparing these compounds, medicaments containing them and the use of these compounds. They have a strong 5-lipoxygenase enzyme inhibiting activity. |
申请人 |
EGYT GYOGYSZERVEGYESZETI GYAR |
发明人 |
SZANTAY, CSABA, DR.;NOVAK, LAJOS, DR.;KOVACS PETER;GADO, KLARA, DR.;GIGLER GABOR;TAKACS BORN JULIANNA;EGYED, ANDRAS, DR.;BOZSING, DANIEL, DR.;PIROK GYOERGY;SZEMEREDI, KATALIN, DR.;CSOERGOE, MARGIT, DR.;DRABANT, SANDOR, DR.;BLASKO, GABOR, DR.;SIMIG, GYULA, DR.;KOVACS, GABOR, DR. |