OXIME DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To obtain a new oxide derivative having strong activity and high safety, and useful as a medicine for preventing and treating hypelipemia, hyperglycemia, obesity, fatty liver, diabetic complication, etc. SOLUTION: This compound is expressed by formula I R<1> is H, a 1-6C (branched)alkyl; R<2> is a 2-6C (branched)alkylene, a halogen, etc.; X is a 6-10C aryl or heterogeneous aromatic group [substituted with one to three 1-6C (branched)alkyl or 1-4C halogenated alkyl groups, etc.,]; Y is O, S, etc.; Z is (3H-2,4,5-trihydro-2,4-dioxo-thiazol-5-yl)methyl, etc.,}, its salt, e.g. 5-(4- 2-[(benzylideneamino)oxo]benzyl)ethoxy] thiazolidine-2,4-dione. The compound of formula I is obtained by reacting a compound of formula II (U is a halogen, etc.) with a compound of formula III (Z'a, Z'b, Z'c and Z'd are the NH-protected groups of Za, Zb, Zc and Zd, respectively) and subsequently removing the protecting groups from reaction product.