| 摘要 |
<p>Moranoline derivatives represented by structural formula (I), wherein R1 represents lower alkyl substituted by acyl, alkoxycarbonyl, cyano, alkylcarbamoyl, nitro, acylamino, alkylthio, hydroxy or aryloxy, phenyl-lower alkyl wherein the benzene ring optionally has substituent(s) such as hydroxy, lower alkoxy, lower alkyl, halogeno, cyano, lower alkylcarbamoyl, nitro, acylamino, alkylthio or carboxy, lower alkyl substituted by a 5-membered unsaturated heterocycle optionally substituted by lower alkyl, alkenyl, arylalkenyl or higher alkyl; R?2 and R3¿ are different from each other and each represents galactopyranosyl or fucopyranosyl substituted by hydroxysulfonyl or a metal salt thereof; and R4 represents hydroxy or acetamide. The compounds are useful in the medicinal field, for example, as an antiinflammatory agent or a preventive or remedy for ischemia and reflow disorders.</p> |
