USE OF ANTISENSE OLIGONUCLEOTIDES TO IL-6 RECEPTOR MRNA TO INHIBIT CELLULAR PROLIFERATION

摘要

The present invention relates to oligonucleotides which are effective inhibitors of disease-associated cellular proliferation. The present invention relates to methods of treating disease-associated cellular proliferation using oligonucleotides. In particular, it relates to the use of oligonucleotides which are substantially complementary to interleukin-6 receptor mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.