| 摘要 |
PURPOSE:To produce lignan lactone useful as a medicine and agricultural chemical in high selectivity and yield, by reducing an acid anhydride obtained from ferulic acid as a raw material with hydrogen using a ruthenium-phosphine complex as a catalyst. CONSTITUTION:An acid anhydride expressed by formula I (R1 and R2 are lower alkoxy or adjacent R1 together form methylenedioxy; R3 is H, OH or alkoxy; m and n are 2-3; the dotted lines are single or double bond) is reduced with hydrogen in the presence of a ruthenium-phosphine complex, e.g. RuH2(PPh3)4 (PPh3 is triphenylphosphine), etc., as a catalyst to afford the aimed lignan lactone expressed by formula II, e.g. dehydromethylretrodendrin, etc. |
