| 摘要 |
1364807 Phenoxy and phenylthio-oxycycloalkane carboxylic esters F HOFFMANN-LA ROCHE & CO AG 24 March 1972 [26 March 1971] 51233/73 Divided out of 1364806 Heading C2C Novel compounds of the Formula I wherein R 1 and R 2 independently are hydrogen, halogen, C 1-7 alkyl, alkoxy or alkylthio, trifluoromethyl, cyano, carbamoyl, carboxy, C 1-7 alkoxycarbonyl, nitro, amino, mono- or di- (C 1-7 alkyl) amino, C 1-7 alkanoyl, aroyl, C 1-7 alkyl- or aryl-amido, sulphamoyl, di-(C 1-7 alkyl)- sulphamoyl or difluoromethyl sulphonyl (at least one carbon atom of the phenyl ring in the ortho-position to the carbon atom linked with the atom X being unsubstituted), R 3 is C 1-7 alkyl, n is 1 or 2, and X is oxygen or sulphur, may be prepared by reacting a phenol or thiophenol II with a haloketo cycloalkane carboxylic acid ester III The compounds of the Formulµ II and III may be prepared as disclosed in Specification 1,364,806. The novel compounds I may be used to prepare the pharmaceutically active compounds of Specification 1,364,806. |
