Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging

摘要

PCT No. PCT/EP93/00027 Sec. 371 Date Dec. 9, 1994 Sec. 102(e) Date Dec. 9, 1994 PCT Filed Jan. 8, 1993 PCT Pub. No. WO93/13808 PCT Pub. Date Jul. 22, 1993The present invention relates to contrast agents comprising microbubble-generating carbohydrate particles having a surfactant admixed within the microparticulate structure, with the proviso that the surfactant is not a saturated C10-20 fatty acid. The contrast agents exhibit useful levels of contrast efficiency and/or stability and may be used in diagnostic applications such as ultrasound and MR imaging.